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Comparison of Human Insulins and Insulin Analogues
Insulin Preparation |
Onset of Action |
Peak Action |
Duration of Action |
Rapid-Acting
Humalog® (lispro)
Novolog® (aspart) |
5-15 minutes
5-15 minutes |
30-90 minutes
40-60 minutes |
4-5 hours
3-5 hours |
Short-Acting
Human regular |
30-60 minutes |
2-4 hours |
6-10 hours |
Intermediate-Acting
NPH/Lente |
1-2 hours |
4-8 hours |
10-20 hours |
Long-Acting
Ultralente
Glargine |
2-4 hours
1-2 hours |
8-20 hours
No peak |
16-24 hours
24 hours |
Data derived from Humalog prescribing information.[1] Data derived from Novolog prescribing information.[2] All other data from Abramowicz [3] and Rosenstock.[4]
References
- Eli Lilly. Humalog prescribing information.
- Novo Nordisk Pharmaceuticals, Inc. Novolog prescribing information.
- Abramowicz M. Drugs for diabetes. Medical Letter. 2002;1:1-6.
- Rosenstock J. Insulin therapy: optimizing control in type 1 and type 2 diabetes. Clin Cornerstone. 2001;4:50-64.
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